2023

Faesel, N., Koch, M., Fendt, M.:
Sex-dependent role of orexin deficiency in feeding behavior and affective state of mice following intermittent access to a Western diet – implications for binge-like eating behavior.
Physiol Behav (2023) 260: 114069. DOI: 0.1016/j.physbeh.2022.114069

El Matine, R., Kreutzmann, J. C., Fendt, M.:
Chronic unilateral inhibition of GABA synthesis in the amygdala increases specificity of conditioned fear in a discriminative fear conditioning paradigm in rats.
Prog Neuropsychopharmacol Biol Psychiatry (2023) 124: 110732

Höhn, L., Hußler, W., Richter, A., Smalla, K.-H., Birkl-Toeglhofer, A.-M., Birkl, C., Vielhaber, S., Leber, S. L., Gundelfinger, E. D., Haybaeck, J., Schreiber, S., Seidenbecher, C. I.:
Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer’s Disease Patients.
Int. J. Mol. Sci. (2023), 24, 5532. https://doi.org/10.3390/ijms24065532

Seifried, L., Soleimanpour, E., Dieterich, D.C., Fendt, M.:
Cognitive flexibility in mice: effects of puberty and role of NMDA receptor subunits.
Cells (2023) 12: 1212. DOI: 10.3390/cells12091212

Jonathan J. Swietlik, Stefanie Bärthel, Chiara Falcomatà, Diana Fink, Ankit Sinha, Jingyuan Cheng, Stefan Ebner, Peter Landgraf, Daniela C. Dieterich, Henrik Daub, Dieter Saur,
Felix Meissner:
Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation.
Nature Communications (2023) 14:2642. DOI.org/10.1038/s41467-023-38171-8

Durairaja, A., Pandey, S., Kahl, E., Fendt, M.:
Nasal administration of orexin A partially rescues dizocilpine-induced cognitive impairments in female C57BL/6J mice.
Behav Brain Res (2023) 450: 114491. DOI: 0.1016/j.bbr.2023.114491

Nossol, C., Landgraf, P., Barta‑Boszormenyi, A., Kahlert, S., Kluess, J.,·Isermann, B.,·Stork, O., Dieterich, D. C., Dänicke, S., Rothkötter, H.-J.:
Deoxynivalenol affects cell metabolism in vivo and inhibits protein synthesis in IPEC‑1 cells.
Mycotoxin Research (2023). Doi.org/10.1007/s12550-023-00489-z

Kiyokawa, Y., Tamogami, S., Ootaki, M., Kahl, E., Mayer, D., Fendt, M., Nagaoka, S., Tanikawa, T., Tekeuchi T.:
An appeasing pheromone ameliorates fear responses in the brain rat (Rattus norvegicus).
iScience26 (2023): 107081. DOI: 10.1016/j.isci.2023.107081

Parsons, M. H., Stryjek, R., Fendt, M., Kiyokawa, Y., Bebas, P., Blumstein, D. T.:
Making the case for the free exploratory paradigm: animal welfare-friendly assays that enhance heterozygosity and ecological validity.
Front Behav Neurosci (2023) 17: 1228478. DOI: 10.3389/fnbehav.2023.1228478

Bernstein, H.-G., Smalla, K.-H., Keilhoff, G., Dobrowolny, H., Kreutz, M. R., Steiner, J.:
The many “Neurofaces” of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders.
Journal of Chemical Neuroanatomy 132 (2023) 102321. DOI.org/10.1016/j.jchemneu.2023.102321

Roig Adam, A., Martinez‑Lopez, J. A., van der Spek, S. J. F., The SYNGO consortium (u. a. Gundelfinger, E. D., Pielot, R., Smalla, K.-H.), Sullivan, P. F., Smit, A. B., Verhage, M., Hjerling‑Leffler, J.:
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal Identity.
Roig Adam et al. Biology Direct (2023) 18:22. Doi.org/10.1186/s13062-023-00372-y

Becker, A., Helmuth, M., Chindo, B. A.:
Effects of Ficus Platyphylla-Induced Hypothermia on Long-term Functional Recovery after Ischaemic Stroke.
OBM Neurobiology (2023): Vol. 7, Issue 4. Doi: 10.21926/obm.neurobiol.2304200

Blondiaux, A., Jia, S., Annamneedi, A., Çalıs¸kan, G., Nebel, J. , Montenegro-Venegas, C., Wykes, R. C., Fejtova, A., Walker, M. C., Stork, O., Gundelfinger, E. D., Dityatev, A., Seidenbecher, C., I.:
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.
Neurobiology of Disease 188 (2023) DOI: 10.1016/j.nbd.2023.106324 

Blondiaux, A.,Jia, S., Annamneedi, A., Çalışkan, G., Schulze, J., Montenegro-Venegas, C., Wykes, R. C., Fejtova, A., Walker, M. C., Stork, O., Gundelfinger, E. D., Dityatev, A., Seidenbecher, C. I.:
Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy.
bioRxiv beta – Cold Spring Harbor Lab. (2023) doi.org/10.1101/2023.04.19.537468

Parsons, M. H., Stryjek, R., Bebas, P., Fendt, M., Blumstein, D. T., Kiyokawa, Y., Chrzanowski, M. M., Munshi-South, J.:
Why are predator cues in the field not more evocative? A ‘real world’ assay elicits subtle, but meaningful, responses by wild rodents to predator scents.
Front. Ecol. Evol. (2023)Vol. 10 DOI: 10.3389/fevo.2022.1054568

Andres-Alonso, M., Grochowska, K. M., Gundelfinger, E. C., Karpova, A., Kreutz, M. R.:
Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications.
Molecular and Cellular Neuroscience 125 (2023) doi.org/10.1016/j.mcn.2023.103854

2022

Demidova, A., Kahl, E., Fendt, M.:
Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment.
Prog Neuropsychopharamcol Biol Psychiatry (2022) 116: 110517. DOI: 10.1016/j.pnpbp.2022.110517

Durairaja, A., Steinecke, C.S., Fendt, M.:
Intracerebroventricular infusion of the selective orexin 1 receptor antagonist SB-334867 impairs cognitive flexibility in a sex-dependent manner.
Behav Brain Res (2022) 424: 113791. DOI: 10.1016/j.bbr.2022.113791

Bicakci, A. O., Sarkar, M., Chang, Y-H, Kahl, E., Ragazzi, L., Moldes-Anaya, A., Fendt, M.:
Anxiolytic-like effects of the positive GABAB receptor modulator GS39783 correlate with mice’s individual basal anxiety and stress reactivity.
Pharmaceuticals (2022) 15: 233. DOI: 10.3390/ph15020233

Musa Itopa Yakubu, Nuhu Mohammed Danjuma, Mohammed Garba Magaji, Sani Malami, Axel Becker, Medinat Yakubu Abbas, Ben Ahmed Chindo:
Co-administration of Zingiber officinale Extract and Sodium Valproate Ameliorates Seizure Severity, Cognitive Deficit, and Neuronal Cell Loss in Pentylenetetrazole-kindled Mice.
OBM Integrative and Complementary Medicine (2022) Volume 7, Issue 1. DOI: 10.21926/obm.icm.2201013

Eckart D. Gundelfinger, Anna Karpova, Rainer Pielot, Craig C. Garner, Michael R. Kreutz: 
Organization of Presynaptic Autophagy-Related Processes.
Front. Synaptic Neurosci. (2022) Volume 14, Article 829354. DOI: 10.3389/fnsyn.2022.829354

Carolina Montenegro-Venegas, Debarpan Guhathakurta, Eneko Pina-Fernandez, Maria Andres-Alonso, Florian Plattner, Eckart D Gundelfinger, Anna Fejtova:
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP.
EMBO Reports (2022) DOI 10.15252/embr.202153659

Md. Abu Bokor Siddik, Markus Fendt:
D-cycloserine rescues scopolamine-induced deficits in cognitive flexibility in rats measured by the attentional set-shifting task.
Behavioural Brain Research 431 (2022), DOI: 10.1016/j.bbr.2022.113961

Tusar Kanta Acharya, Ashutosh Kumar, Rakesh Kumar Majhi, Shamit Kumar, Ranabir Chakraborty, Ankit Tiwari, Karl-Heinz Smalla, Xiao Liu, Young-Tae Chang, Eckart D. Gundelfinger, Chandan Goswami:
TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism.
Mitochondrion 67 (2022) 38–58, DOI: 10.1016/j.mito.2022.10.001

Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, … The SynGO Consortium, et al.:
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Nature Volume 604, 502 – 508 (2022), DOI: 10.1038/s41586-022-04434-5

Priyadharshini Prabhakar, Rainer Pielot, Peter Landgraf, Josef Wissing, Anne Bayrhammer, Marco van Ham, Eckart D. Gundelfinger, Lothar Jänsch, Daniela C. Dieterich, Anke Müller:
Monitoring regional astrocyte diversity by cell type-specific proteomic labeling in vivo.
Glia (2022); 1–22, DOI: 10.1002/glia.24304

Iris Müller, Markus Fendt:
Fear Conditioning in Laboratory Rodents.
Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats. Neuromethods (2022) Volume 190. DOI: 10.1007/978-1-0716-2748-8

2021

Kreutzmann, J. C., Marin, M.-F., Fendt, M., Milad, M. R., Ressler, K., Jovanovic, T.:
Unconditioned response to an aversive stimulus as predictor of response to conditioned fear and safety: a cross-species study.
Behav Brain Res 402 (2021): 113105.  DOI:10.1016/j.bbr.2020.113105

Faesel, N., Kolodziejczyk, M. H., Koch, M., Fendt, M.:
Orexin deficiency affects sociability and the acquisition, expression, and extinction of conditioned social fear.
Brain Res 1751 (2021): 147199. DOI: 10.1016/j.brainres.2020.147199

Soleimanpour, E., Bergado Acosta, J.R., Landgraf, P., Mayer, D., Dankert, E., Dieterich, D.C., Fendt, M.:
Regulation of CREB phosphorylation in nucleus accumbens after relief conditioning.
Cells 10 (2021): 238. DOI: 10.3390/cells10020238

Kreutzmann, J. C., Fendt, M.: 
Intranasal oxytocin compensates for estrus cycle-specific reduction of conditioned safety memory in rats: implications for psychiatric disorders.
Neurobiol Stress (2021) 14: 100313. DOI: 10.1016/j.ynstr.2021.100313

Faesel, N., Schünemann, M., Koch, M., Fendt, M.:
Angiotensin II-induced drinking behavior as a method to verify cannula placement into the cerebral ventricles of mice: an evaluation of its accuracy.
Physiol Behav (2021) 232: 113339. DOI: 10.1016/j.physbeh.2021.113339

Harb, M., Jagusch, J., Durairaja, A., Endres, T., Leßmann, V.,Fendt, M.:
BDNF haploinsufficiency induces behavioral endophenotypes of schizophrenia in male mice that are rescued by enriched environment.
Transl Psychiatry (2021) 11: 233. DOI: 10.1038/s41398-021-01365-z

French, T., Israel, N., Düsedau, H., P., Tersteegen, A., Steffen, J., Cammann, C., Topfstedt, E., Dieterich, D.,Schüler, T., Seifert, U., Dunay, I. R.:
The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis.
Frontiers in Immunology (2021) April, Volume 12, Article 619465. DOI: 10.3389/fimmu.2021.619465

Fendt, M., Kreutzmann, J., Jovanovic, T.,
Editorial: Learning safety to reduce fear: recent insights and potential implication.
Behav Brain Res (2021) 411: 113402. DOI: 10.1016/j.bbr.2021.11340

Bicakci, A.O., Tsai, P.L., Kahl, E., Mayer, D., Fendt, M.: 
Dissociative effects of neuropeptide S receptor deficiency and nasal neuropeptide S administration on T-maze discrimination and reversal learning.
Pharmaceuticals (2021) 14: 643. DOI: 10.3390/ph14070643

Becker, A., Helmuth, M., Trzeczak, D., Chindo, B. A.:
Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice.
Journal of Ethnopharmacology 278 (2021) 114219

Ghelani, T., Montenegro-Venegas, C., Fejtova, A., Dresbach, T.:
Nanoscopical Analysis Reveals an Orderly Arrangement of the Presynaptic Scaffold Protein Bassoon at the Golgi-Apparatus
Mol. Neuroscience (2021), Vol. 14, Article 744034

Henning Peter Düsedau, Johannes Steffen, Caio Andreeta Figueiredo, Julia Désirée Boehme, Kristin Schultz, Christian Erck, Martin Korte, Heidi Faber-Zuschratter, Karl-Heinz Smalla, Daniela Dieterich, Andrea Kröger, Dunja Bruder, Ildiko Rita Dunaya:
Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.
mBio (2021) Volume 12 Issue 5, e01776-21

Juncal Fernández-Orth, Leoni Rolfes, Lukas Gola, Stefan Bittner, Joseph Andronic, Vladimir L. Sukhorukov, Dmitri Sisario, Peter Landgraf, Daniela C. Dieterich, Manuela Cerina, Karl-Heinz Smalla, Thilo Kähne, Thomas Budde, Stjepana Kovac, Tobias Ruck, Markus Sauer, Sven G. Meuth:
A role for TASK2 channels in the human immunologicalsynapse.
Eur. J. Immunol. (2021) 51: 342–353, DOI: 10.1002/eji.201948269

2020

Hoffmann-Conaway, S., Brockmann, M. M., Schneider, K., Annamneedi, A., Rahman, K. A., Bruns, C., Textoris-Taube, K., Trimbuch, T., Smalla, K.-H., Rosenmund, C., Gundelfinger, E. D., Garner, C. C., Montenegro-Venegas, C.:
Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.
eLife (2020);9:e56590. DOI.org/10.7554/eLife.56590

Montenegro‑Venegas, C., Fienko, S., Anni, D., Pina‑Fernandez, E., Frischknecht, R., Fejtova, A.:
Bassoon inhibits proteasome activity via interaction with PSMB4.
Cellular and Molecular Life Sciences (2020). DOI.org/10.1007/s00018-020-03590-z

Montenegro-Venegas, C., Annamneedi, A., Hoffmann-Conawaye, S., Gundelfinger, E. D., Garner, C. C.:
BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy. 
Autophagy (2020), DOI: 10.1080/15548627.2020.1801259

Kolodziejczyk, M.H., Fendt, M.:
Corticosterone treatment and incubation time after contextual fear conditioning synergistically induce fear memory generalization in neuropeptide S receptor-deficient mice.
Front Neurosci (2020) 14: 128

Kreutzmann, J.C., Khalil, R., Köhler, J.C., Mayer, D., Florido, A., Nadal, R., Andero, R., Fendt, M.:
Neuropeptide-S-receptor deficiency affects sex-specific modulation of safety learning by pre-exposure to electric stimuli.
Gen Brain Behav (2020) 19: e12621

Kreutzmann, J.C., Fendt, M.:
Chronic inhibition of GABA synthesis in the infralimbic cortex facilitates conditioned safety memory and reduces contextual fear.
Trans Psychiatry (2020) 10: 120. DOI: 10.1038/s41398-020-0788-8.

Wöhr, M., Willadsen, M., Kisko, T.M., Schwarting, R.K.W., Fendt M.:
Sex-dependent effects of Cacna1c haploinsufficiency on behavioral inhibition evoked by conspecific alarm signals in rats.
Prog Neuropsychopharmacol Biol Psychiatr (2020) 99: 109849. DOI: 10.1016/j.pnpbp.2019.109849

Fendt, M., Parsons, M.H., Apfelbach, R., Carthey, A.J.R., Dickman, C.R., Endres, T., Frank, A.S.K., Heinz, D.E., Jones, M.E., Kiyokawa, Y., Kreutzman, J.C., Roelofs, K., Schneider, M., Sulger, J., Wotjak, C.T., Blumstein, D.T.:
Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis.
Neurosci Biobehav Rev (2020) 115: 25-33. DOI: 10.1016/j.neubiorev.2020.05.002

Kolodziejczyk, M.H., Faesel, N., Koch, M., Fendt, M.:
Sociability and extinction of conditioned social fear is affected in neuropeptide S receptor-deficient mice.
Behav Brain Res (2020) 393: 112782. DOI: 10.1016/j.bbr.2020.112782 Kreutzmann, J.C., Jovanovic, T., Fendt, M.: Psychopharmacology (2020) 237: 2161-2172. DOI: 10.1007/s00213-020-05527-7

Kreutzmann, J.C., Jovanovic, T., Fendt, M.:
Infralimbic cortex activity is required for the expression but not the acquisition of conditioned safety.
Psychopharmacology (2020) 237:2161-2172

Kaushik, R., Lipachev, N., Matuszko, G., Kochneva, A., Dvoeglazova, A., Becker, A., Paveliev, M., Dityatev., A.:
Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia.
Eur J Neurosci. 2020;00:1-17

Uzuneser, T.C., Fendt, M.:
Individual expression of conditioned safety but not of conditioned relief is correlated with contextual fear. 
Behav Brain Res (2020) 393: 112799. DOI: 10.1016/j.bbr.2020.112799

Cornelius, A.D.A., Hosseini, S., Schreier, S., Fritzsch, D., Weichert, L., Michaelsen-Preusse, K., Fendt, M., Kroeger, A.:
Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
J Neuroinflamm (2020) 17: 278. DOI: 10.1186/s12974-020-01951-w

Durairaja, A., Fendt, M.:
Orexin deficiency modulates cognitive flexibility in a sex-dependent manner. 
Genes Brain Behav (2020) e12707. DOI: 10.1111/gbb.12707

Fernández-Orth, J., Rolfes, L., Gola, L., Bittner, S., Andronic, J., Sukhorukov, V. L., Sisario, D., Landgraf, P., Dieterich, D. C., Cerina, M., Smalla, K.-H., Kähne, T., Budde, T., Kovac, S., Ruck, T., Sauer, M., Meuth, S. G.:
A role for TASK2 channels in the human immunological Synapse.
Eur. J. Immunol. (2020) 00: 1–12 DOI: 10.1002/eji.201948269

Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons.

Fernandez, A., Corvalan, K., Santis, O., Mendez-Ruette, M., Caviedes, A., Pizarro, M., Gomez, M. T., Federico Batiz, L., Landgraf, P., Kahne, T., Rojas-Fernandez, A., Wyneken, U.:

Brain Res. (2023):148679. doi: 10.1016/j.brainres.2023.148679. Online ahead of print.PMID: 37972846