2004

Ammon-Treiber S and Höllt V.:
Morphine-induced changes of gene expression in the brain. Addiction Biology. 2004 in press

Ammon-Treiber S, Grecksch G, Stumm R, Riechert U, Tischmeyer H, Reichenauer A, Höllt V.:
Rapid, transient, and dose-dependent expression of hsp70 messenger RNA in the rat brain after morphine treatment. Cell Stress Chaperones. 2004 ; 9(2):182-97.

Ammon-Treiber S, Tischmeyer H, Riechert U, Höllt V.:
Gene expression of transcription factors in the rat brain after morphine withdrawal. Neurochem Res. 2004; 29(6):1267-73.

Becker A., Grecksch G.:
Ketamine-induced changes in rat behavior: a possible animal model of schizophrenia. Test of predictive validity. Progr. in Neuro-Psychopharm. & Biolog. Psychiatry, 28 (2004) 1267-1277

Beyer A., Koch T., Schröder H., Schulz S., Höllt V.:
Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human µ-opioid receptor. J. of Neurochemistry, 2004, 89, 553-560

Börner C., Kraus J., Schröder H., Ammer H., Höllt V.:
Transcriptional Regulation of the Human µ-Opioid Receptor Gene by Interleukin-6. Molecular Pharmacology 2004, 66: 1719-1726

Börner C.,Wöltje M., Höllt V., Kraus J. :
STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and µ-opioid receptors
J. of Neurochemistry, 2004, 91, 1493-1500

Grecksch G., Becker A., Schröder H., Kraus J., Loh H., Höllt V.:
Accelerated kindling development in µ-opioid receptor deficient mice.. Naynyn-Schmiedeberg's Arch. Pharmacol. 369 (2004) 287-293

Koch T., Brandenburg L.-O., Liang Yingjian, Schulz S., Beyer A., Schröder H., Höllt V.:
Phospholipase D2 modulates agonist-induced µ-opioid receptor desensitization and resensitization. J. of Neurochemistry, 2004, 88, 680-688

Raghavendra Y.N., Grecksch G., Reymann K.G., Schröder H., Becker A.:
Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits. Naynyn-Schmiedeberg's Arch. Pharmacol. 370 (2004) 26-34

Schulz S., Mayer D., Pfeiffer M., Stumm R., Koch T., Höllt V.:
Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J. (2004), 23:3282-3289

Stumm R.K., Zhou Chun, Schulz S., Höllt V.:
Neuronal Types Expressing µ- and d-Opioid Receptor mRNA in the Rat Hippocampal Formation. J. of Comparat. Neurology, 469, (2004), 107-118

Stumm R.K., Zhou Chun, Schulz S., Endres M., Kronenberg G., Allen JP., Tulipano G., Höllt V.:
Somatostatin Receptor 2 Is Activated in Cortical Neurons and Contributes to Neurodegeneration after Focal Ischemia. The Journal of Neuroscience, 2004, 24 (50): 11404-11415

Tulipano G., Summ R., Pfeiffer M., Kreienkamp H.-J., Höllt V., Schulz S.:
Differential b-Arrestin Trafficking and Endosomal Sorting of Somatostatin Receptor Subtypes. J. Biol. Chem., 2004, 279(20):21374-21382

weitere Publikationen 2004

Keilhoff G., Becker A., Grecksch G., Wolf, G., Bernstein HG.:
Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia. Neuroscience, 2004; 126 (3): 591 - 8

Burne TH., Becker A., Brown J., Eyles DW., Mackay-Sim A., McGrath JJ.:
Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats. Behav. Brain Res., 2004 Oct. 5; 154 (2): 549-55

Keilhoff G.,Bernstein HG., Becker A., Grecksch G., Wolf, G.:
Increased Neurogenesis in a Rat Ketamine Model of Schizophrenia. Biol. Psychiatry 2004, 56: 317-322

Nagaraja RY., Grecksch G., Reymann KG., Schröder H., Becker A.:
Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling and kindling-related learning deficits. Naunyn-Schmiedeberg's Arch. Pharmacol. 2004, 370: 26-34

Mawrin C., Schulz S., Pauli SU.,Treuheit T., Dietzmann K., Firschimg R., Schulz S., Höllt V.:
Differential expression of sst1, sst2A and sst3 somatostatin receptor proteins in low-grade and high-grade astrocytomas. J. Neuropathol. Exp. Neurol. 2004 Jan., 63(1): 13-9

Unger N., Serdiuk I., Sheu SY., Walz MK., Schulz S., Schmid KW., Mann., Petersenn S.:
Immunohistochemical Determination of Somatostatin Receptor Subtypes 1, 2A, 3, 4 and 5 in Various Adrenal Tumors. Endocrine Research 2004, Vol. 30, No. 4, 931-934

Schulz Solveig, Röcken Ch., Mawrin Ch., Weise W., Höllt V., Schulz S.:
Immunocytochemical Identification of VPAC1, VPAC2 and PAC1 Receptors in Normal and Neoplastic Human Tissues with Subtype-Specific Antibodies. Clinical Cancer Res. 10 (2004) 8235-8242

2003

Ammon S., Mayer P., Riechert U., Tischmeyer H., Höllt V.:
Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated with drawal. Mol Brain Res. 2003 Apr 10;112(1-2):113-25.

Becker A., Peters B., Schroeder H., Mann T., Huether G., Grecksch G.:
Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia. Progr. in Neuro-Psychopharm. & Biol. Psychiatry 27 (2003) 687-700.

Becker A., Grecksch G.:
Haloperidol and clozapine affect social behaviour in rats postnatally lesioned in the ventral hippocampus. Pharm., Biochem. and Behavior 76 (2003) 1-8

Koch T., Brandenburg L.-O., Schulz S., Liang Y., Klein J., Höllt V.:
ADP-ribosylation factor-dependent phospholipase D2 activations is required for Agonist-induced µ-opioid receptor endocytosis. J. of Biol. Chem. 278 (2003) 9979-9985.

Kraus J, Börner C, Giannini E, Hollt V.:
The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol. 2003 Oct;64(4):876-84.

Kraus J., Börner C., Hollt V.:
Distinct palindromic extensions of the 5'-TTC...GAA-3' motif allow STAT6 binding in vivo. FASEB J. 2003 Feb;17(2):304-6.

Mayer P., Kroslak T., Tischmeyer H., Hollt V.:
A truncated delta opioid receptor, spontaneously produced in human but not rat neuroblastoma cells, interferes with signaling of the full-length receptor. Neurosci Lett. 2003 Jun 19;344(1):62-4.

Pfeiffer M., Kirscht S., Stumm R., Koch T., Wu D., Laugsch M., Schroder H., Hollt V., Schulz S.:
Heterodimerization of Substance P and {micro}-Opioid Receptors Regulates Receptor Trafficking and Resensitization. J Biol Chem. 2003 Dec 19;278(51):51630-51637.

Stumm RK., Zhou C., Ara T., Lazarini F., Dubois-Dalcq M., Nagasawa T., Hollt V., Schulz S.:
CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci. 2003 Jun 15;23(12):5123-30.

weitere Publikationen 2003

Bernstein H.-G., Becker A., Keilhoff G., Spilker C., Gorczyca W.A., Braunewell K.-H., Grecksch G.:
Brain region-specific changes in the expression of calcium sensor proteins after repeated Applications of ketamine to rats. Neurosci. Letters 339(2003) 95-98.

Schmoll H., Badan I., Grecksch G., Walker L., Kessler C.,Popa-Wagner A.:
Animal Model Kindling status in sprague-dawley rats induced by pentylenetetrazol. Involvement of a critical development period. Am. J. Pathol. 162 (2003) 1027-1034.

Stirnweiss J.,Hartrodt B., Grecksch G., Stürzebecher U., Böhmer F.-D., Neubert K., Liebmann C.:
Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with µ-opioid receptor-sensitizing properties. British J. of Pharmacology (2003) 140, 13-22

Ichikawa H., Schulz S., Höllt V., Sugimoto T.:
The somatostatin sst2A receptor in the rat trigeminal ganglion. Neuroscience. 2003;120(3):807-13.

Mundschenk J., Unger N., Schulz S., Höllt V., Schulz S., Steinke R., Lehnert H.:
Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy. J. Clin Endocrinol Metab. 2003 Nov;88(11):5150-7.

Stepanyan Z., Kocharyan A.,Pyrski M., Hubschle T., Watson A. M., Schulz S., Meyerhof W.:
Leptin-target neurones of the rat hypothalamus express somatostatin receptors. J. Neuroendocrinol.2003 Sept 15(9):822-30

Hortala M., Ferjoux G., Estival A., Bertrand C., Schulz S., Pradayrol  L., Susini C.,  Clemente F.:
Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of   JA K2. J Biol Chem.2003 Jun 6;278 (23): 20574-81. Epub 2003 Mar 27

2002

Becker A., Grecksch G., Kraus J., Loh H.H., Schröder H., Höllt V.:
Rewarding effects of ehtanol and cocaine in µ opioid receptor-deficient mice. Naynyn-Schmiedeberg's Arch. Pharmacol. 365 (2002) 296-302.

Börner Ch., Höllt V., Kraus J.:
Involvement of Activator Protein-1 in Transcriptional Regulation of the Human µ-Opioid Receptor Gene. Mol.Pharmacology 61 (2002) 800-805

Braun H., Schulz S., Höllt V.:
Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Brain Res. 930 (2002) 191-199.

Braun H., Schäfer K., Höllt V.:
bIII Tubulin-Expressing Neurons Reveal Enhanced Neurogenesis in Hippocampal and Cortical Structures after a Contusion Trauma in Rats. J. of Neurotrauma 19 (2002) 975-983

Höllt V.:
A polymorphism (A118G) in the µ-opioid receptor gene affects the response to morphine-6-glucuronide in humans. Pharmacogenetics 12 (2002) 1-2

Koch T., Schulz S., Höllt V.:
Different IntracellularSignaling Systems Involved in Opioid Tolerance/Dependence. in Molecular Biology of Drug Addiction, Humana Press Inc. (2002) 45-60

Kraus J., Börner Ch., Höllt V.:
Distinct palindromic extensions of the 5'-TTC...GAA-3' motif allow STAT6 binding in vivo. The FASEB Journal (2002)

Mayer P.,Erdtmann-Vourliotis M., Höllt V.:
Molekulare Grundlagen der Opiatabhängigkeit. Molecular Mechanisms of Opiate Addiction. SUCHT: Zeitschrift für Wissenschaft und Praxis 48/1 (2002) 17-28.

Mayer P., Ammon S., Braun H., Tischmeyer H., Riechert U., Kahl E., Höllt.:
Gene expression profile after intense second messenger activation in cortical promary neurones. J. Neurochem. 82 (2002) 1077-1086.

Mayer P., Erdtmann-Vourliotis M., Riechert U., Ammon S., Höllt V.:
Mild stress sensitizes the brain's response to morphine. Mol. Brain Res. 104 (2002) 143-147.

Pfeiffer M., Koch T., Schröder H., Laugsch M., Höllt V., Schulz S.:
Heterodimerization of Somatostatin and Opioid Receptors Crossmodulates Phosphorylation, Internalization and Desensitization. J. of Biological Chemistry 277(2002) 19762-19772

Schröder H., Koch T., Schulz S., Höllt V.:
Activity of mGluR I can modulate the µ-opiate receptor desensitization in HEK 293 cells. Neuropharmacology 43 (2002) 308.

Schulz S.:
Verteidigung, Regulation und Funktion von Opioid- und Somatostatin-Rezeptoren im zentralen Nervensystem. Magdeburg, Univ., Medizin. Fak., Habil.-Schr., 2002

Stumm R., Rummel J., Junker V., Culmsee C., Pfeiffer M., Krieglstein J., Höllt V., Schulz S.:
A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in Adult Brain: Isoform-Selective Regulation of SDF-1 Expression Modulates CXCR4-Dependent Neuronal Plasticity and Cerebral Leukocyte Recruitment after Focal Ischemia. J. of Neuroscience 22 (2002) 5865-5878

weitere Publikationen 2002

Ambrosch A., Müller R., Freytag C., Borgmann S., Kraus J., Dierkes J., Neumann K.H., König W.:
Small-sized low-density lipoproteins of subclass B from patients withe end-stage renal disease effectively augment tumor necrosis factor-a-induced adhesive properties in human Endothelial cells. American J. of Kidney Diseases 39 (2002) 972-984.

Borgmann S., Bayer A., König W., Ambrosch A, Kraus J.:
Constrasting effects of long-term treatment with IFN-g in endothelial cells: Increase in IL-6 sectretion versus decrease in IL-8 secretion, NF-kB, and AP-1 activation. Endothelium 9 (2002) 173-178.

Kulaksiz H., Eissele R., Rössler D., Schulz S., Höllt V. , Cetin Y., Arnold R.:
Identification  of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies. Gut 50 (2002) 0-9.  

Rössler A.-S., Rüthrich H., Krug M., Dodd R.H., Chapouthier G., Grecksch G.:
Long-lasting potentiation effects induced in rats by kindling with an inverse agonist of the benzodiatepine receptor. Exp. Brain Res. 146 (2002) 77-85

Stogmann E., Zimprich A., Baumgartner C., Aull-Watschinger S., Höllt V., Zimprich F.:
A functional polymorphismen in the prodynorphin gene promotor is associated with temporal lobe epilepsy. Ann. Neurol. 51 (2002) 260-263.

Vasilaki A., Mouratidou M., Schulz S., Thermos K.:
Somatostatin mediates nitric oxide production by activating sst(2) receptors in the rat retina. Neuropharmacology 43 (2002) 899-909

Allen J.P., Canty A.J., Schulz S., Humphrey P.P.A., Emson P.C., Young H.M.:
Identification of Cells Expressing Somatostatin Receptor 2 in the Gastrointestinal Tract os Sstr2 Knockout/lacZ Knockin Mice. J. of Comp. Neurology 454 (2002) 329-340